一、基本信息

姓名：袁泓明

职称：副教授

所在部门：bevictor伟德

研究方向：基因表达与调控

办公电话：15504495057

电子邮件：yuanhongming@jlu.edu.cn

二、学习与工作经历

2011.09 - 2015.06  南昌大学 生物科学专业 理学学士

2015.09 - 2020.09  BETVLCTOR伟德官方网站 生物化学与分子生物学 硕博连读

2020.10 - 2022.12  bevictor伟德  鼎新学者（博士后）

2023.01 - 2023.09  bevictor伟德 讲师

2023.10 - 至今     bevictor伟德 副教授

三、主要科研工作（包括科研项目）

1. 国家自然科学基金青年基金项目，32202754，30 万，2023.1-2025.12，项目负责人；

2. 横向课题，非洲猪瘟诊断试剂开发，3R1220266205，100万，2022.6.-2024.5，项目负责人；

3. 转基因生物新品种培育重大专项，2018ZX08010，290 万，参与。

4. 国家重点研究计划，2019YFA0110702，747 万，参与。

四、科研成果（著作、专利、论文）

(1) Hongming Yuan^#, Tingting Yu, Lingyu Wang, Lin Yang, et al. Efficient base editing by RNA‑guided cytidine base editors (CBEs)in pigs. Cellular and Molecular Life Sciences, 2019 Jul 13.

(2) Ziru Wang^#; Hongming Yuan^#*; Lin Yang; et al. Decreasing predictable DNA off-target effects and narrowing editing windows of adenine base editors by fusing human Rad18 protein variant. International Journal of Biological Macromolecules, 2023 Dec 31. （并列一作及并列通讯作者）

(3) Hongming Yuan^#, Lin Yang, Yuanzhu Zhang, et al. Current Status of Genetically Modified Pigs That Are Resistant to Virus Infection, Viruses, 2022, Feb 17.

(4) Lin Yang , Ziru Wang , Hongsheng Ouyang, Yuanzhu Zhang , Wenyu Xiao , Ying Liu, Jiacheng Deng , Mengjing Li , Lerong Ma, Chunyun Qi , Daxin Pang *, Hongming Yuan*. Porcine ZC3H11A Is Essential for the Proliferation of Pseudorabies Virus and Porcine Circovirus 2. ACS infectious diseases, 2022,May 13.

(5) Jiacheng Deng, Lin Yang, Ziru Wang, Hongsheng Ouyang, Hao Yu, Hongming Yuan*, Daxin Pang*. Advance of genetically modified pigs in Xeno-Transplantation. Frontiers in cell and developmental Biology, 2022.Oct 10.

(6) Yiwu Chen, Yuanzhu Zhang, Xi Wang, Jian Zhou, Lerong Ma, Jianing Li, Lin Yang, Hongsheng Ouyang, Hongming Yuan*, Daxin Pang*.Transmissible Gastroenteritis Virus: An Update Review and Perspective.Viruses, 2023, Feb 15.

(7) Mengjing Li^#, Hongsheng Ouyang^#, Hongming yuan, Jianing Li, Zicong Xie, et al. Site-Specific Fat-1 Knock-In Enables Significant Decrease of n-6PUFAs/n-3PUFAs Ratio in Pigs. Genes Genomes Genetics. 2018 May 4.

(8) Qiangbing Yang, Hongming Yuan, Mao Chen, et al. Metformin ameliorates the progression of atherosclerosis via suppressing macrophage infiltration and inflammatory responses in rabbits. Life sciences, 2018 Apr 1.

(9) Zicong Xie#, Daxin Pang#, Hongming Yuan, Huping Jiao, et al. Genetically modified pigs are protected from classical swine fever virus. Plos Pathogens, 2018 Dec 13.

(10) Kankan Wang, Xiaochun Tang, Zicong Xie, Xiaodong Zou, Mengjing Li, Hongming Yuan, Nannan Guo, Hongsheng Ouyang, Huping Jiao, Daxin Pang. CRISPR/Cas9-mediated knockout of myostatin in Chinese indigenous Erhualian pigs. Transgenic Research, 2017 Dec 26.

(11) Lu Chao, Daxin Pang, Zicong Xie, Xiaodong Zou, Mengjing Li, Hongming Yuan, Nannan Guo, Hongsheng Ouyang, Huping Jiao, Daxin Pang. CRISPR/Cas9-Mediated Hitchhike Expression of Functional shRNAs at the Porcine miR-17-92 Cluster . Cells, 2019 Feb 1.

(12) Zhiquan Liu, Mao Chen, Huanhuan Shan, Siyu Chen, Yuxin Xu, Yuning Song, Quanjun Zhang, Hongming Yuan, Hongsheng Ouyang, Zhanjun Li, Liangxue Lai. Expanded targeting scope and enhanced base editing efficiency in rabbit using optimized xCas9(3.7). Cellular and Molecular Life Sciences, 2019 Apr 27.

(13) Mengjing Li, Xiaochun Tang, Wenni You, Yanbing Wang, Yiwu Chen, Ying Liu, Hongming Yuan, Chuang Gao, Xue Chen, Xiaodong Zou, Hongsheng Ouyang, Daxin Pang. HMEJ-mediated site-specific integration of a myostatin inhibitor increases skeletal muscle mass in porcine. Molecular Therapy Nucleic Acids, 2021 Jun 24.

(14) Kankan Wang, Xiaochun Tang, Yan Liu, Zicong Xie, Xiaodong Zou, Mengjing Li, Hongming Yuan, Hongsheng Ouyang, Huping Jiao, Daxin Pang. Efficient Generation of Orthologous Point Mutations in Pigs via CRISPR-assisted ssODN-mediated Homology-directed Repair. Molecular Therapy Nucleic Acids, 2016 Nov 29.

(15) Jiahuan Chen, Beiying An, Biao Yu, Xiaohuan Peng, Hongming Yuan, Qiangbing Yang, Xue Chen, Tingting Yu, Lingyu Wang, Xinwei Zhang, He Wang, Xiaodong Zou, Daxin Pang, Hongsheng Ouyang, Xiaochun Tang. CRISPR/Cas9-mediated knockin of human factor IX into swine factor IX locus effectively alleviates bleeding in hemophilia B pigs. Haematologica, 2021.Mar 1.

(16) Zicong Xie, Daxin Pang, Kankan Wang, Mengjing Li, Nannan Guo, Hongming Yuan, Jianing Li, Xiaodong Zou, Huping Jiao, Hongsheng Ouyang, Zhanjun Li, Xiaochun Tang. Optimization of a CRISPR/Cas9-mediated Knock-in Strategy at the Porcine Rosa26 Locus in Porcine Foetal Fibroblasts. Scientific Reports, 2017 Jun 8.

五、获授权发明专利

1. 欧阳红生，袁泓明，逄大欣；一种有效抑制II型PRRSV感染的基因序列及其应用，ZL 2018 1 0952139.4，中国。